Indometh {nls} | R Documentation |

## Pharmacokinetics of Indomethicin

### Description

The `Indometh`

data frame has 66 rows and 3 columns of data on
the pharmacokinetics of indomethicin.

### Usage

data(Indometh)

### Format

This data frame contains the following columns:

- Subject
- an ordered factor with containing the subject codes. The
ordering is according to increasing maximum response.
- time
- a numeric vector of times at which blood samples were drawn (hr).
- conc
- a numeric vector of plasma concentrations of indomethicin (mcg/ml).

### Details

Each of the six subjects were given an intravenous injection of
indomethicin.

### Source

Kwan, Breault, Umbenhauer, McMahon and Duggan (1976),
“Kinetics of Indomethicin absorption, elimination, and
enterohepatic circulation in man”,
*Journal of Pharmacokinetics and Biopharmaceutics*, **4**,
255–280.

Davidian, M. and Giltinan, D. M. (1995) *Nonlinear Models for
Repeated Measurement Data*, Chapman & Hall (section 5.2.4, p. 134)

Pinheiro, J. C. and Bates, D. M. (2000) *Mixed-effects Models in
S and S-PLUS*, Springer.

### Examples

data(Indometh)
fm1 <- nls(conc ~ SSbiexp(time, A1, lrc1, A2, lrc2),
data = Indometh, subset = Subject == 1)
summary(fm1)